Fig 2. Graphical representation of CDSeq probabilistic model.

The light blue nodes, α, β, denote the hyperparameters that are assumed to be known. The dark blue nodes, ℓ, g_ij, r_ij, denote the values of observable random variables (either measured in the study or established in previous studies) whereas the white nodes, η, Φ, θ, c_ij, are unobservable random variables that need to be inferred from data. The outer box represents samples where M is the sample size, and the inner box denotes the RNA-Seq data of a sample where N is the total number of reads from the sample (see S1 Methods for details).