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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Stat Med. 2018 Dec 4;38(8):1357–1373. doi: 10.1002/sim.8040

TABLE 3.

Candidate loci interrogated in transcriptome association analysis

# SNPs*
Gene§ Chr Start Stop Biomarker○ (1) (2) (3)
COL5A2 1 189896640 190044605 CRP 7 2 1
PDIA5 6 122785855 122880953 CRP 38 12 6
LRRC16A 20 25279655 25620758 IL-6 341 63 20
§

Previously identified genes associated with biomarkers at the p < 5 × 10−6 level in the GENE study include: Collagen Type V Alpha 2 Chain (COL5A2), Protein Disulfide Isomerase Family A Member 5 (PDIA5) and Capping Protein Regulator And Myosin 1 Linker 1 (CARMIL1, previously LRRC16A).

○

Biomarker associations correspond to resting state (baseline) C-reactive protein (CRP) or change from baseline to peak after stimulus interleukin-6 (IL-6).

*

A subset of SNPs within each gene are used in the transciptome association analysis. Here (1) represents the number of SNPs in the original GENE study data; (2) represents the number of SNPs in both the GENE study and the DGN data; (3) represents the number of SNPs remaining after LD pruning using a threshold of 0.20.