TABLE 4.

Transcriptome-biomarker association analysis

		γ0	γ1	σ	β0	β1*	α
EM§:
COL5A2	estimate:	−0.377	−0.00914	1.118	3.126	−0.354	1.162
	std err:	0.179	0.00735	−	0.0346	0.0713	−
	test stat:	−2.113	−1.243	−	90.450	−4.970	−
	p-value:	0.0346	0.214	−	< 0.001	< 0.001	−
PDIA5	estimate:	−0.256	−0.00100	1.122	5.654	0.0904	4.003
	std err:	0.413	0.00128	−	0.0415	0.0285	−
	test stat:	−0.784	−0.619	−	136.104	3.176	−
	p-value:	0.536	0.433	−	< 0.001	0.002	−
LRRC16A	estimate:	4.362	0.00118	1.501	5.0286	−0.288	3.281
	std err:	0.346	0.00184	−	0.132	0.0370	−
	test stat:	12.609	0.656	−	38.049	−7.781	−
	p-value	< 0.001	0.523	−	< 0.001	< 0.001	−
Regression Imputation:
CoL5A2	estimate:	1.966	−0.119	1.075	3.123	−0.343	1.160
	std err:	0.638	0.0297	−	0.0346	0.0726	−
	test stat:	3.083	−4.015	−	90.917	−4.726	−
	p-value:	0.002	< 0.001	−	< 0.001	< 0.001	−
PDIA5	estimate:	0.529	−0.00348	1.120	5.651	0.0913	4.002
	std err:	0.920	0.00290	−	0.0415	0.0284	−
	test stat:	0.575	−1.203	−	158.692	2.937	−
	p-value:	0.566	0.231	−	< 0.001	0.002	−
LRRC16A	estimate:	4.166	0.00228	1.491	5.039	−0.288	3.280
	std err:	0.530	0.00292	−	0.131	0.0370	−
	test stat:	7.859	0.780	−	38.509	−7.789	−
	p-value	< 0.001	0.436	−	< 0.001	< 0.001	−

^§Coefficient estimates and standard errors are based on application of the EM strategy using a convergence criterion of < 1 × 10−6. Convergence is reached at 34 iterations for COL5A2, 71 iterations for PDIA5 and 34 iterations for LRCC16A.

^*The coefficient estimate and corresponding standard error is reported for the strongest signal SNP within each gene (rs9467471 for LRCC16A; rs836861 for PDIA5).