. Author manuscript; available in PMC: 2020 Apr 15.

Published in final edited form as: Stat Med. 2018 Dec 4;38(8):1357–1373. doi: 10.1002/sim.8040

TABLE 5.

Transcriptome-biomarker association analysis

		γ₀	γ₁	σ_ϵ	β₀	β₁^*(rs6938645)	σ_δ
Unified likelihood^§:

LRRC16A	estimate:	4.650	0.157	1.195	−0.435	−0.915	0.651
	std err:	0.092	0.127	−	0.153	0.0431	−
	test stat:	50.653	1.238	−	−2.851	−21.212	−
	p-value:	< 0.001	0.216	−	0.004	< 0.001	−

Regression Imputation:

LRRC16A	estimate:	4.649	0.153	1.207	−0.431	−0.914	0.659
	std err:	0.092	0.126	−	0.155	0.0437	−
	test stat:	50.397	1.213	−	−2.789	−20.939	−
	p-value:	< 0.001	0.227	−	0.005	< 0.001	−

^§

Coefficient estimates and standard errors are based on application of the unified likelihood strategy.

The coefficient estimate and corresponding standard error is reported for the strongest signal SNP within LRCC16A (rs6938645).