Table 3.
PSSG proteins and pathways identified in AD.
| α-enolase | Glycolysis, apoptotic signaling | Reduction of function | ↑ |
| α-crystallin B | Heat-inducible chaperone | Reduction of function | ↑ |
| Deoxyhemoglobin | Oxygen transport | Increased oxygen affinity | ↑ |
| Glyceraldehyde 3-phosphate dehydrogenase | Glycolysis, apoptotic signaling | Reduction of function | ↑ |
| Na,K-ATPase | Sodium-potassium pump | Reduction of function | N/A |
| Insulin degrading enzyme | Degradation of insulin and Aβ | Reduction of function | N/A |
| p53 | Tumor suppressor | Potential decrease in formation of active tetramer | ↑ |
| Transthyretin | Thyroxin/retinol transport | N/A | ↑ |