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. 2019 Dec 11;4(6):e00824-19. doi: 10.1128/mSphere.00824-19

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Copyright © 2019 Elizaldi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — Association between rectal microbiome composition and HIV-1 antibody responses. (A) Violin plots show stability of rectal Lactobacillus over DNA immunization. (B) Relative abundance of Lactobacillus at DNA3 week 0 correlates with HIV-1 gp140 IgA in rectal secretions. (C) Violin plots show the relative abundance of Clostridium IV over time (D) and correlation between Clostridium IV and rectal gp140 IgG, and gp120 IgG levels. (E) Frequency of CD28⁻ CD95⁺ CD4 T cells at week 1 after DNA3 immunization correlate with contemporaneous abundance of Prevotella. (F) Prevotella abundance is a negative predictor of HIV-1 gp140 IgG and gp120 IgG in rectal secretions. Significance was tested by Spearman rank correlation test.