Table 1:
Baseline clinical characteristics of the study participants
| Relamorelin (n=10) |
Placebo (n=12) |
p-value | |
|---|---|---|---|
| Age (years) | 28.9 ± 2.4 | 28.9 ± 1.9 | 0.99 |
| % Ideal body weight | 79.9 ± 1.5 | 81.0 ± 2.1 | 0.67 |
| Weight (kg) | 48.1 ± 1.5 | 48.9 ± 1.8 | 0.73 |
| Height (cm) | 165.2 ± 2.3 | 165.3 ± 1.9 | 0.97 |
| BMI (kg/m2) | 17.6 ± 0.4 | 17.8 ± 0.4 | 0.58 |
| Duration of anorexia nervosa (years) | 13.2 ± 2.2 | 14.8 ± 2.2 | 0.60 |
| Gastric emptying time (minutes)* | 89 [69.5, 110.8] | 85.5 [74.0, 125.8] | 0.60 |
| Resting energy expenditure (kcals/day) | 1040 ± 40 | 1055 ± 53 | 0.83 |
| Beck Depression Inventory-2 score | 15.2 ± 2.8 | 12.3 ± 2.1 | 0.41 |
| Visual Analog Scale – Hungry* | 6.3 [2.2, 8.1] | 3.0 [1.0, 5.5] | 0.15 |
| Total ghrelin (pg/ml)* | 878 [722, 1191] | 1131 [825, 1263] | 0.34 |
| Acylated ghrelin (pg/ml)* | 162 [118, 293] | 140 [52, 366] | 0.65 |
| Desacyl ghrelin (pg/ml)* | 422 [225, 678] | 444 [318, 599] | 0.87 |
| IGF-1 (ng/ml) | 156 ± 10 | 171 ± 14 | 0.39 |
| Serum glucose (mg/dL) | 77.8 ± 2.3 | 83.1 ± 2.4 | 0.13 |
Mean ± SEM
median [interquartile range]