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. 2019 Dec 6;9:1376. doi: 10.3389/fonc.2019.01376

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Copyright © 2019 Deville and Cordes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular matrix (ECM), cellular end nuclear stiffness are regulated by several factors. The ECM remodeling is highly dependent on cancer associated fibroblasts (CAFs). The cell stiffness instead is regulated by integrins and focal adhesion proteins (FAPs), which contribute to cancer radio- and drug-resistance by mediating cell adhesion to the extracellular matrix. Upon cell adhesion to ECM, integrins induce pro-survival signaling cascades mediating radiotherapy- and drug-resistance (CAM-RR and CAM-DR). Finally, the nuclear stiffness is regulated by the levels of lamin-A/C and chromatin condensation. Created with BioRender.