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. 2019 Dec 12;9:18941. doi: 10.1038/s41598-019-55379-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Toxicity of compound 1 and efficacy of compound 1 and 5-Fluorocytosine in C. elegans infected with C. albicans or C. auris. (a) Adult (L4-stage) worms were exposed to compound 1 at four different concentrations and viability was recorded daily for four days. Adult (L4-stage) worms were infected with the highly-virulent, fluconazole-resistant strains (b) C. albicans P60002 or (c) C. auris strain 390 for 90 minutes at 25 °C. Worms were washed and then treated with compound 1 (either at 5 µg/mL or 10 µg/mL), 5-Fluorocytosine (5-FC, 5 µg/mL) or left untreated. Survival of worms was monitored daily and recorded. Data are presented as a Kaplan-Meier survival curve.