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. 2019 Dec 12;10:5689. doi: 10.1038/s41467-019-13705-1

Fig. 1. Sonogashira-type enantioselective oxidative cross-coupling of C(sp3)−H bonds with terminal alkynes.

Fig. 1

a Previous ionic-type dehydrogenative coupling of C(sp3)—H bonds adjacent to nitrogen. b Our proposal: tandem HAA and copper-catalyzed Sonogashira-type coupling. c Amide-directed enantioselective coupling of C(sp3)−H bonds with terminal alkynes. HAA hydrogen atom abstraction, [ox] oxidant, SET single-electron transfer.