Fig. 3. Substrate scope of N-fluorocarboxamides.

a The reaction is compatible with a variety of (hetero)aryl-fused N-fluorocarboxamide substrates. b Linear N-fluorocarboxamides are also applicable under slightly modified conditions. ^aStandard conditions: 1 (0.2 mmol), alkyne (0.4 mmol), CuI (10 mol%), L5 (10 mol%), and Cs₂CO₃ (1.0 equiv.) in THF (2.4 mL) at rt for 16 h. ^bIsolated yield based on 1. ^cEe values based on HPLC analysis. ^dL6 (10 mol%) was used in DCM at rt for 24 h. ^eL7 (Table 1, 10 mol%) was used in CHCl₃ at rt for 24 h.