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. 2019 Dec 12;9:18983. doi: 10.1038/s41598-019-55528-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FXR1 forms SDS-resistant oligomers and aggregates in rat brain. (a) FXR1 is present in brain in fraction of oligomers and insoluble aggregates. Total protein lysate was divided into fractions of monomers less than 100 kDa, oligomers larger than 100 kDa, and insoluble aggregates. The fractions were subjected to SDD-PAGE and analyzed by immunoblotting with anti-FXR1 antibodies. (b) Relative intensity of bands corresponding to FXR1 monomers, oligomers and insoluble aggregates is represented as mean ± SEM for three independent brain samples. (c) A large portion of FXR1 in rat brain forms SDS-resistant aggregates. Total rat brain lysate was treated with1% SDS at RT, subjected to SDD-AGE, and analyzed by immunoblotting with anti-FXR1 antibodies. (d) Relative intensity of bands corresponding to FXR1 monomers and SDS-resistant aggregates is represented as mean ± SEM for three independent brain samples.