Table 1.

Discovery and replication analyses to identify SNPs associated with CSC.

	SNP	rs13278062						rs6061548
	Nearby genes	TNFRSF10A-LOC389641 (in gene)						GATA5 (Nearby)
	Effect allele	T						T
	CHR: position	8: 23082971						20: 61033892
Stage	Ethnicities	CSC		Control		OR (95% CI)	P	CSC		Control		OR (95% CI)	P
		N	EAF	N	EAF			N	EAF	N	EAF
Discovery GWAS	Japanese	610	0.421	2850	0.345	1.38 (1.22–1.57)	5.94 × 10−7*	610	0.138	2850	0.088	1.64 (1.36–1.98)	2.52 × 10−7*
Replication stage 1	Japanese	277	0.392	5449	0.324	1.35 (1.13–1.60)	8.97 × 10−4*	278	0.128	4546	0.095	1.39 (1.07–1.80)	0.0128*
Replication stage 2	Japanese	137	0.409	1153	0.368	1.19 (0.92–1.53)	0.189*	137	0.161	1153	0.077	2.29 (1.60–3.27)	5.55 × 10−6*
Replication stage 3	European	521	0.591	3577	0.520	1.36 (1.18–1.56)	1.47 × 10−5†	521	0.082	3577	0.051	1.60 (1.23–2.07)	5.80 × 10−4†
Meta-analysis of Japanese Data (discovery + replication 1 + replication 2)
	Japanese	1024		9452		1.34 (1.22–1.48)	1.45 × 10−9	1025		8549		1.64 (1.43–1.89)	3.38 × 10−12
Meta-analysis of Japanese Data and European Data
	Japanese and European	1545		13,029		1.35 (1.24–1.46)	1.26 × 10−13	1546		12,126		1.63 (1.44–1.85)	5.36 × 10−15

All meta-analyses were performed using a fixed-effect model

CHR chromosome, EAF effect allele frequency, CSC central serous chorioretinopathy, OR odds ratio, CI confidence interval

*P-values were derived using logistic regression analysis. ^†P-values were derived using association analysis