Table 2.
Cox-regression analysis of progression-free (a) and disease-specific (b) survival with genomic clustering.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
| (a) Progression-free survival | ||||||
| Primary tumor site | ||||||
| Trunk (vs Extremity)a | 5.22 | (2.08–13.10) | 4.29 × 10−4** | 4.29 | (1.59–11.58) | 4.01 × 10−3** |
| Surgical margin | ||||||
| (R2, R1, R0) | 2.25 | (1.33–3.81) | 2.52 × 10−3** | 1.62 | (0.87–3.01) | 0.131 |
| Genomic cluster | ||||||
| Cluster 1 (vs 2) | 1.82 | (1.08–3.04) | 0.0234* | 2.31 | (1.33–4.00) | 2.84 × 10−3** |
| Cluster 3 (vs 2) | 0.399 | (0.55–2.92) | 0.365 | 1.12 | (0.14–8.85) | 0.912 |
| (b) Disease-specific survival | ||||||
| Primary tumor site | ||||||
| Trunk (vs Extremity)a | 8.14 | (1.10–60.06) | 0.0397* | 5.93 | (0.76–46.21) | 0.0894 |
| Surgical margin | ||||||
| (R2, R1, R0) | 2.70 | (1.16–6.26) | 0.0207* | 2.23 | (0.84–5.86) | 0.106 |
| Genomic cluster | ||||||
| Cluster 1 (vs 2) | 2.86 | (1.28–6.39) | 0.0104* | 3.18 | (1.35–7.48) | 8.07 × 10−3** |
| Cluster 3 (vs 2) | 1.38 × 10−8 | (0–Inf) | 0.999 | 1.55 × 10−7 | (0–Inf) | 0.998 |
CI confidence interval, HR hazard ratio
The results are presented for the univariate and multivariate Cox-regression analysis for progression-free and disease-specific survival, using clinical measures and genomic cluster. Kaplan–Meier survival curves according to the SCNA regions are shown in Fig. 3. *P < 0.05, **P < 0.01
aTrunk includes abdomen, retroperitoneum, chest wall, and back, and extremity includes extremity, shoulder, and girdle