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. 2019 Dec 12;9:18958. doi: 10.1038/s41598-019-55603-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multiple imputations performed to attribute values to the subjects who did not complete the study protocol. The imputations had a mean difference of 3.41% between the observed outcomes (blue) and the imputed ones (red). Each adverse event is described in two lines according to its presence (yes or no), and in two columns according to the inclusion or not of imputed data: the left columns show only the results from patients who complete the follow-up, while the right columns show results obtained by combining the observed data and the imputed ones.