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. 2019 Dec 12;9:18954. doi: 10.1038/s41598-019-55505-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Involvement of miR-204-3p in the inhibited integrin/FAK cascade and the suppressed cell migration and invasion of human CRC cell DLD-1 in response to delphinidin. (A) Cells were treated with delphinidin (DEL) at 100 μM for 24 h, and then the cells were lysed for RNA extraction and microRNA expression profiling by using microarray analysis. MicroRNAs with up-regulation and down-regulation in response to delphinidin were labeled with red and green color, respectively. (B) Cells were transfected with control vector (NC) or anti-miR-204-3p, treated with delphinidin for 24 h, and then lysed for the assessment of integrin expression and FAK activation by Western blotting. (C) Cells were transfected with control vector or anti-miR-204-3p, treated with delphinidin for 24 h, and then subject to the transmigration and invasion assay. Quantitative data was acquired from three independent experiments and presented as mean ± standard deviation. * and **P < 0.05 and P < 0.01 as compared to the DMSO control (0 μM).