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. 2019 Dec 12;10:5688. doi: 10.1038/s41467-019-13604-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Schematic procedure to investigate effects of CAP-H2 condensin KD on the maintenance of OIS. IMR90 cells were infected with retrovirus encoding H-RasV12 and cultured for 9 days to establish OIS (Methods). OIS cells were then infected with lentivirus encoding one of the three shRNA constructs (#1, #2, and #3) against CAP-H2 gene (NCAPH2) or carrying an empty vector (control) and harvested 3 days after the lentivirus infection. b–d Effect of CAP-H2 KD on maintenance of OIS. Cells prepared as in panel a were subjected to DAPI (b), SA-β-gal (c), and BrdU (d) staining. P-values were calculated by two-sided Student’s t-test, using biologically independent samples (n = 3, error bars represent the SD).