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. 2019 Dec 12;9:18924. doi: 10.1038/s41598-019-55045-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in iDC-induced spike rate activation after spike rate adaptation. (A,B) Individual (grey) and population (coloured) spike rate change in response to anodic (+) and cathodic (−) 2-s long iDC steps (protocol as in Fig. 2) after adaptation to a constant +10 µA (A) or −10 µA (B) baseline, applied for 60 s before steps. (C) Mean spike rate change in response to anodic (+) and cathodic (−) iDC across different baselines (+10 µA, 0 µA and −10 µA). There was a significant interaction between baseline and step amplitude (2way RM ANOVA; p = 0.0382; n = 10 recordings). At the greatest cathodic intensity (−20 µA), when compared to the 0 µA baseline control, the elicited change in spike rate was larger for the +10 µA baseline (Holm-Sidak multiple comparisons; p = 0.0016) and smaller for the −10 µA baseline (p = 0.0288). At the greatest anodic intensity (+20 µA), the change in spike rate was smaller for the +10 µA baseline (p = 0.0222) but not significantly different for the −10 µA baseline (p = 0.3129). Error bars are ±SEM.