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. 2019 Dec 12;7(23):e14232. doi: 10.14814/phy2.14232

Figure 3.

Figure 3

Saliva secretion and ion concentrations of the ex vivo SMG under β‐adrenergic and cholinergic stimulation. Mouse SMG was ex vivo perfused for 10 min with the β‐adrenergic receptor agonist IPR (1.0 μmol/L) and the cholinergic receptor agonist CCh (0.3 μmol/L) in a HCO3 −‐containing physiological perfusion solution. (A) The kinetics and rates of salivation (μL/min) were not significantly different between Slc4a11+/+ (white circles, n = 15) and Slc4a11 −/− mice (black circles, n = 17). (B) The saliva amounts (μL) of the ex vivo SMG for Slc4a11+/+ (white bar, n = 15, 7 males and 8 females; white circles = males, black circles = females) and Slc4a11 −/− mice (gray bars, n = 17, 8 males and 9 females; white circles = males, black circles = females). (C) The Na+ and Cl− concentrations in saliva from Slc4a11 −/− mice (gray bars, n = 17, 8 males and 9 females; white circles = males, black circles = females) than Slc4a11+/+ mice (white bar, n = 15, 7 males and 8 females; white circles = males, black circles = females) (*P < 0.01). The saliva K+ concentrations decreased (**P < 0.05) in the Slc4a11 −/− mice. Data shown for individual glands (circles) along with the means ± SEM.