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. 2019 Dec 12;7(23):e14232. doi: 10.14814/phy2.14232

Figure 4.

Figure 4

Saliva secretion and ion concentrations of the ex vivo SMG under cholinergic stimulation. Mouse ex vivo SMG was perfused for 10 min with the cholinergic receptor agonist CCh (0.3 μmol/L) in a HCO3 −‐containing physiological perfusion solution. (A) The kinetics and rates of salivation (μL/min) in glands from Slc4a11+/+ (white circles, n = 8) and Slc4a11 −/− (black circles, n = 9) mice. (B) The saliva amounts (μL) of the ex vivo SMG for Slc4a11+/+ (white bar, n = 8, 4 males and 4 females; white circles = males, black circles = females) and Slc4a11 −/− mice (gray bars, n = 9, 4 males and 5 females; white circles = males, black circles = females). (C) The Na+ and Cl− concentrations in saliva of Slc4a11 −/− mice (gray bars, n = 9, 4 males and 5 females; white circles = males, black circles = females) compared to Slc4a11+/+ mice (white bars, n = 8, 4 males and 4 females; white circles = males, black circles = females). The saliva HCO3 − concentrations increased in the Slc4a11 −/− mice. Data shown for individual glands (circles) along with the means ± SEM (**P < 0.01).