Table 4.

Intracellular pH acidification and alkalization rates in empty vector‐ and Slc4a11‐transfected CHO‐K1 cells.

Solutions	Inhibitors	Acidification rate (10−3/sec, pH 7.4–6)				Alkalization rate (10−3/sec, pH 7.4–9)
		Empty vector	n	Slc4a11	n	Empty vector	n	Slc4a11	n
HCO3 −‐free		0.40 ± 0.16	12	1.99 ± 0.27**	16	0.16 ± 0.14	12	3.22 ± 0.40**	16
	10 μmol/L EIPA	0.20 ± 0.11	5	2.66 ± 0.20**	15	0.08 ± 0.04	5	2.79 ± 0.21**	15
	200 μmol/L EIPA	0.40 ± 0.13	7	1.13 ± 0.14	18	0.22 ± 0.21	7	2.26 ± 0.20**	18
	500 μmol/L EIPA	0.48 ± 0.14	5	0.48 ± 0.10	10	0.04 ± 0.04	5	0.46 ± 0.09	10
	500 μmol/L DIDS	0.43 ± 0.11	4	2.50 ± 0.17**	12	0.10 ± 0.09	4	3.78 ± 0.33**	12
HCO3 −‐ & Na+‐free		0.68 ± 0.10	14	1.45 ± 0.19**	11	0.10 ± 0.03	14	3.08 ± 0.49**	11
HCO3 −‐ & Cl−‐free		0.28 ± 0.10	6	1.73 ± 0.26**	8	0.27 ± 0.14	6	3.60 ± 0.39**	8

Values are the means ± SEM, n represents the number of individual transfections in each experiment.

^** P < 0.01, empty vector‐ versus Slc4a11‐transfected CHO‐K1 cells.