Table 3.

Longitudinal Volume Changes for Abstainers and Relapsers

Region	Hemisphere and subregion	Main Effects		Simple Effects P-values		Volume Percent Change AP1 to AP2
		Group Main Effect	Days Abstinent (Time) Main Effect	ABS	REL	ABS	REL
Anterior Cingulate	Left Caudal	NS	NS	.10	NS	5.1	0.6
	Right Caudal	NS	NS	NS	.018	3.9	1.7
	Left Rostral	F(1, 116) = 4.3, p = .041	NS	NS	NS	0.7	0.2
	Right Rostral	.060	NS	NS	NS	4.5	1.5
Orbitofront al	Left Medial	NS	F(1, 63) = 6.8, p = .012	.014	.004	2.2	3.4
	Right Medial	NS	F(1, 63) = 5.5, p = .022	.060	NS	1.7	−0.3
	Left Lateral	F(1, 116) = 4.8, p = .031	F(1, 64) = 21.2, p < .001	NS	<.001	0.0	0.9
	Right Lateral	.065	F(1, 64) = 10.7, p = .002	.09	.01	0.7	0.5
Dorsal Prefrontal	Left Caudal Middle Frontal	NS	F(1, 63) = 9.6, p = .003	.041	.013	0.8	1.8
	Right Caudal Middle Frontal	NS	NS	NS	NS	1.5	2.2
	Left Rostral Middle Frontal	.097	F(1, 63) = 7.8, p = .007	NS	.017	0.9	2.2
	Right Rostral Middle Frontal	F(1, 115) = 5.9, p = .017	F(1, 63) = 5.8, p = .019	NS	.030	0.0	0.6
	Left Superior Frontal	.058	F(1, 64) = 4.4, p = .040	.017	NS	1.2	1.0
	Right Superior Frontal	F(1, 115) = 5.0, p = .027	F(1, 64) = 4.9, p = .030	.037	NS	1.2	1.1
Precentral	Left	F(1, 115) = 5.9, p = .017	F(1, 64) = 7.0, p = .010	NS	.10	0.1	0.8
	Right	F(1, 115) = 8.7, p = .004	.070	NS	NS	0.0	0.6
Insula	Left	NS	F(1, 64) = 18.9, p < .001	NS	<.001	0.6	2.4
	Right	NS	F(1, 64) = 4.9, p < .031	NS	.057	0.2	1.7
Total Frontal Cortical	Left	F(1, 115) = 6.0, p = .015	F(1, 64) = 13.6, p < .001	.028	.008	1.0	1.0
	Right	F(1, 115) = 6.8, p = .010	F(1, 64) = 10.7, p = .002	.049	.014	0.6	0.7

Note. Full statistics are provided for significant main effects (p < .05) and p-values only for statistical trends for main effects (i.e., p ≤.10); p-values are provided for simple effects. P-values > .10 for any test listed as not significant (NS);

ABS: Abstainers; REL: Relapsers.