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. Author manuscript; available in PMC: 2020 Dec 13.
Published in final edited form as: J Physiol. 2019 Jul 7;599(9):2483–2498. doi: 10.1113/JP277459

Figure 9. Analyses of mEPSCs recorded in neurons expressing A-Glu tau.

Figure 9.

A, comparison of mEPSC amplitudes in neurons expressing native tau and the A-Glu variant (neither contains the P301L mutation). B, quantification of mEPSC frequencies. C, relative cumulative frequency of amplitudes of all mEPSC events in both groups. These results indicate that phosphorylation of A-domain alone is not sufficient to cause synaptic deficits. The results here and the results in Fig. 3 suggest that the phosphorylation of A-domain residues plays a minimal role in tau-induced synaptic deficits over the time period observed (11–14 days after transfection). However, whether the A-domain is involved in spine loss or cell death at later stages remains to be determined. In A and B, data were analysed with Student’s t test; n = 12 neurons; error bars are mean ± SD. In C, data were analysed by the Kolmogorov–Smirnov GOF test.