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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Med Res Rev. 2019 Jun 13;40(1):158–189. doi: 10.1002/med.21599

FIGURE 1.

FIGURE 1

Schematic representation of electron transfers from NADPH to heme through FAD and FMN (via tetrahydrobiopterin). The double-headed arrow indicates a conformational change to bring FMN into proximity with heme. The exact catalytic mechanism is not shown. Figure adapted with permission195