Fig. 3.

Hspg2^Δ3/Δ3 genotype does not alter glucose tolerance or insulin secretion assessed by an IPGTT a) Glucose tolerance in response to intraperitoneal glucose was significantly poorer in hIAPP mice (filled triangle) vs WT mice (open circle) over 120 min; P < 0.05. Glucose tolerance was not different between hIAPP mice (filled triangle) and hIAPP;Hspg2^Δ3/Δ3 mice (open triangle). b) Insulin response to intraperitoneal glucose was decreased in hIAPP (filled triangle) compared to WT (open circle) mice; P ≤ 0.05. Insulin response was not different between hIAPP mice (filled triangle) and hIAPP;Hspg2^Δ3/Δ3 mice (open triangle. c) Insulin secretion was decreased in hIAPP mice (filled triangle) compared to WT mice (open circle); *P < 0.05. Insulin secretion was not different between hIAPP mice (filled triangle) and hIAPP;Hspg2^Δ3/Δ3 mice (open triangle). n = 6–12