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. 2019 Dec 6;13:546. doi: 10.3389/fncel.2019.00546

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Copyright © 2019 Laredo, Plebanski and Tedeschi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pericytes’ role in Alzheimer’s disease (AD) pathogenesis. Pericyte degeneration causes neurovascular uncoupling and blood-brain barrier (BBB) breakdown. Through the accumulation of blood products, BBB disruption triggers vascular-mediated secondary neuronal injury, degeneration and cognitive impairment in AD. Given that pericytes are able to clear Aβ, pericyte loss also results in Aβ accumulation in the brain. Aβ can cause constriction of brain capillaries at pericyte locations. Created with biorender.com.