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. 2019 Dec 6;9:419. doi: 10.3389/fcimb.2019.00419

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Copyright © 2019 Singulani, Galeane, Ramos, Gomes, dos Santos, de Souza, Palma, Fusco Almeida and Mendes Giannini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of different concentrations of MK58911 (MK – 1/2 × MIC; MIC and 2 × MIC), amphotericin B (AMB–MIC), or fluconazole (FLC–MIC) on C. neoformans membrane, evaluated by percentage of propidium iodide (PI)-positive cells at (A) 4 h and (B) 24 h. ^*p < 0.05 compared to control group. Representative images of C. neoformans (C) non-treated cells or (D) cells treated at MIC of amphotericin B (E) MIC of fluconazole or (F) MIC of MK58911 at 4 h. The cell wall of all fungal cells was stained with calcofluor (blue), and cells with membrane damage were stained with propidium iodide (red). Scale bar: 20 μm.