Table 1.
Minimal inhibitory concentration (MIC in μg/mL) for Cryptococcus and Paracoccidioides species, half maximal inhibitory concentration (IC50 in μg/mL) in MRC5 cell line (lung fibroblasts) and U87 cell line (glioblastoma), and selectivity index (SI) of MK58911.
| MK58911 | Amphotericin B | Fluconazole | Itraconazole | |
|---|---|---|---|---|
| C. neoformans | 31.2 | 0.12 | 1 | – |
| C. gattii | 15.6 | 0.12 | 8 | – |
| P. brasiliensis | 7.8 | 0.12 | – | 0.008 |
| P. lutzii | 15.6 | 0.25 | – | 0.008 |
| IC50-MRC5 | >500 | – | – | – |
| IC50-U87 | >500 | – | – | – |
| SI (IC50/MIC) | >16* | – | – | – |
*
Related to C. neoformans.