Table 2.
MRI data
| MRI 0 | MRI 1 | MRI 3 | p Value of comparison MRI 0–1 | p Value of comparison MRI 1–3 | |
|---|---|---|---|---|---|
| Total white matter lesion volume (ml, mean ± SD) | 3.26 ± 3.99 | 3.20 ± 4.23 | 3.61 ± 4.84 | .21 | <.001 |
| White matter lesion increase (ml; mean ± SD) | – | 0.36 ± 0.83 | 0.52 ± 1.19 | – | 0.056 |
| White matter lesion shrinking (ml; mean ± SD) | – | −0.42 ± 0.93 | −0.11 ± 0.32 | – | <.001 |
| Number of new white matter lesions (mean ± SD; range) | – | 1.01 ± 1.81; 0–10 | 2.11 ± 3.69; 0–21 | – | <.001 |
| Number of gadolinium‐enhancing white matter lesions (mean ± SD; range) | 0.73 ± 2.21; 0–16 | 0.32 ± 1.05; 0–9 | 0.17 ± 0.74; 0–7 | .024 | .183 |
| White matter volume (ml; mean ± SD) | 487.1 ± 56.5 | 484.2 ± 55.2 | 481.4 ± 54.1 | <.001 | <.001 |
| Gray matter volume (ml; mean ± SD) | 654.1 ± 66.3 | 648.7 ± 64.9 | 641.7 ± 62.0 | <.001 | <.001 |
Time points were compared by paired t test (white matter volume, gray matter volume, total white matter lesion volume) and related samples Wilcoxon signed‐rank test (new white matter lesions, gadolinium‐enhancing white matter lesions, white matter lesion increase, and white matter lesion shrinking).
For MRI 3, changes in number and volume of white matter lesions are given with respect to MRI 1.
Abbreviations: ml, milliliter; MRI, magnetic resonance imaging; SD, standard deviation.