Table 4.
Regression analysis of white matter lesion shrinking between MRI 1 and 3 with demographic and other MRI parameters
| Dependent variable: WML shrinking MRI 1–3 | Coefficient | 95% Confidence interval | p | |
|---|---|---|---|---|
| Lower bound | Upper bound | |||
| (Constant) | .373 | −0.691 | 1.436 | .489 |
| Age | .001 | −0.004 | 0.006 | .699 |
| Sex | −.035 | −0.137 | 0.068 | .504 |
| Disease duration | .006 | −0.011 | 0.024 | .463 |
| Time interval MRI 1–3 | −.001 | −0.002 | 0.001 | .475 |
| Escalation therapy MRI 3 | −.089 | −0.180 | 0.001 | .053 |
| WML volume MRI 1 | −.032 | −0.075 | 0.011 | .145 |
| Gd + WML MRI 1 | −.053 | −0.100 | −0.006 | .026 |
| GM volume change MRI 1–3 | −.001 | −0.004 | 0.002 | .516 |
| WM volume change MRI 1–3 | .015 | 0.008 | 0.022 | .000 |
Abbreviations: DMDs, disease modifying drugs; Gd, Gadolinium; GM, gray matter; MRI, magnetic resonance imaging; n.s., not significant; WM; white matter; WML, white matter lesion