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. 2019 Nov 20;43(1):31–40. doi: 10.3892/or.2019.7413

Figure 4.

Figure 4.

miR-145 is identified as a potential target of FTH1P3. (A) Alignment of potential FTH1P3 base pairing with miR-145 as identified by miRcode. (B) Cervical cancer cells were transfected with the overexpression plasmid of FTH1P3 [pcDNA-3.1(+)-FTH1P3] or negative control. Expression of lncRNA FTH1P3 was measured by qRT-PCR. (C and D) Cervical cancer cells were transfected with lncRNA FTH1P3 or siRNA FTH1P3 combined with miR-145 mimic or mimic control. Expression of miR-145 was assessed by qRT-PCR. (E) Wild-type (lncR-FTH1P3-WT) or mutant (lncR-FTH1P3-Mut) luciferase reporter and/or miR-145 mimic were co-transfected into cervical cancer cells to determine the luciferase activity. Data are presented as the means ± SD of three independent experiments. *P<0.05 and **P<0.01 compared with lncRNA-FTH1P3 WT group. MicroRNA-145, miR-145; FTH1P3, ferritin heavy chain 1 pseudogene 3.