Table II.
Network of 22 differentially expressed genes identified in the CHST15 knockdown cells related to cell proliferation and apoptosis processes showing interactions with CHST15.
| Gene symbol | Fold change | Location | Family |
|---|---|---|---|
| APCDD1 | −2.249056649 | Plasma membrane | Other |
| BMP2 | 2.552303689 | Extracellular space | Growth factor |
| BTG2 | −1.801089658 | Nucleus | Transcription regulator |
| CCND1 | −1.574172163 | Nucleus | Transcription regulator |
| CHST15 | −2.578621457 | Plasma membrane | Enzyme |
| CLU | −1.726946433 | Cytoplasm | Other |
| CREM | 1.573881221 | Nucleus | Transcription regulator |
| EEF1A1 | −1.600578387 | Cytoplasm | Translation regulator |
| HSPA5 | −1.588890827 | Cytoplasm | Enzyme |
| LEPR | 1.966722394 | Plasma membrane | Transmembrane receptor |
| MIR17HG | 1.509101665 | Other | Other |
| NF1 | 1.510434197 | Cytoplasm | Other |
| PLAU | 1.906482559 | Extracellular space | Peptidase |
| PMAIP1 | 1.714217298 | Cytoplasm | Other |
| PTHLH | 2.256082774 | Extracellular space | Other |
| PTK2 | −1.699664502 | Cytoplasm | Kinase |
| SAE1 | −1.840426328 | Cytoplasm | Enzyme |
| TGFA | −1.540818218 | Extracellular space | Growth factor |
| TIMP3 | −1.590628214 | Extracellular space | Other |
| TPM1 | 1.923481561 | Cytoplasm | Other |
| USO1 | −2.010930656 | Cytoplasm | Transporter |
| WNT5A | −1.526294473 | Extracellular space | Cytokine |
CHST15, carbohydrate sulfotransferase 15; APCDD1, APC down-regulated 1; BMP2, bone morphogenetic protein 2; BTG2, BTG anti-proliferation factor 2; CCND1, cyclin D1; CLU, clusterin; CREM, cAMP responsive element modulator; EEF1A1, eukaryotic translation elongation factor 1 α 1; HSPA5, heat shock protein family A (Hsp70) member 5; LEPR, leptin receptor; MIR17HG, miR-17-92a-1 cluster host gene; NF1, neurofibromin 1; PLAU, plasminogen activator, urokinase; PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1; PTHLH, parathyroid hormone like hormone; PTK2, protein tyrosine kinase 2; SAE1, SUMO1 activating enzyme subunit 1; TGFA, transforming growth factor-α; TIMP3, TIMP metallopeptidase inhibitor 3; TPM1, tropomyosin 1; USO1, USO1 vesicle transport factor; WNT5A, Wnt family member 5A.