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. 2019 Oct 25;43(1):41–54. doi: 10.3892/or.2019.7389

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Oncogenic roles of iRhom1 and iRhom2 knockdown on HeLa cells. (A) Expression of iRhom1 and iRhom2 (western blotting) in cells transfected with iRhom1 or iRhom2 shRNA for 72 h. Knockdown of iRhom1 suppressed its expression by 80.8% (***P<0.01) and knockdown of iRhom2 suppressed its expression by 72.2% (***P<0.01). (B) Changes over time in the viability (OD₄₉₀ in MTT assay) of cells transfected with shCtrl, shRhom1, and shRhom2 (**P<0.05). (C) Colonies of cells formed following transfection with shCtrl, shRhom1, and shRhom2 (**P<0.05). iRhom1, inactive rhomboid protein 1; iRhom2, inactive rhomboid protein 2.