Fig. 7.

Using the Technical University of Munich (TUM) hand-held curvilinear system: a case of breast with 15 mm × 20 mm invasive lobular breast carcinoma. (A) US image revealing tumor (solid orange arrowhead) centered at 17 mm deep. (B) Composite MSOT image, revealing disruption of the layered organization of tissue around the tumor. Significant is that part of the tumor has low MSOT values, while strong Hb signals are seen clustered in a smaller part (hollow orange arrowhead). (C) Anti-CD31 IHC stained tumor slice in post-surgical pathology confirms high vascularity (hollow orange arrowhead), next to an avascular region (red arrowheads). (D) H&E stained slice adjacent to the one in panel (C) shows carcinoma (dotted line and yellow arrowheads) next to avascular fibroadenoma (red arrowheads). Scale bars (A and B) 5 mm. Scale bars (C and D) 2 mm. (Reproduced with permission of the authors and publisher.)