Fig. 1.

Structural characterization of hearts from WT and Gly790del DSC2 knock-in (KI) mice. A. Representative images of hematoxylin/eosin-stained long axis section of hearts from WT and KI mice at the age of 1-year-old, and Azan stained RV wall. No right ventricular dilatations and fibrosis or fatty infiltration were observed even in homozygous KI mice. B, C. Representative images of echocardiogram and the summarized echocardiographic parameters in WT and KI mice. Only in homozygous KI mice, LV dilatation and decrease in % fractional shortening (FS) was observed after 6-month-old. Data represent means ± SEM of 9–12 mice.