Table 3.
Biological linkages of gastrin and/or CCK to pancreatic islets.
| Peptide(s) | Linkage | References |
|---|---|---|
| Gastrin | Expression in islet G-cells during foeto-/neonatal life | 3-7 |
| CCK | Intra-islet CCK neurones | 8, 42 |
| Gastrin and CCK | CCK2 receptor expression on islet cells | 16, 17, 58, 60, 61 |
| CCK | Expression in β-cells during obesity | 10, 11, 62 |
| Gastrin | Islet-cell neogenesis and increase in the insulin secretion in hypergastrinaemia | 65, 67, 69, 71-74 |
| Gastrin and CCK | Neuroendocrine pancreatic tumours | 77-82 |
| Gastrin and CCK | Incretin effect, also during meals | 64, 84 |
| Gastrin and CCK | Potentiation of other incretins | 74, 85, 86 |
| Gastrin | Expression preceding islet-cell neogenesis after pancreatic duct-ligation | 75 |
Abbreviation: CCK, cholecystokinin.