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. 2019 Oct 31;31:67–84. doi: 10.1016/j.molmet.2019.10.006

Figure 5.

Figure 5

iRhom2 KO mice are less prone to HFD-induced insulin resistance. A-D Fasting glycemia (A) serum insulin concentration (B) homeostatic model assessment of insulin resistance index (HOMA-IR), (C) and quantitative insulin sensitivity check index (QUICKI) (D) in iRhom2 KO and WT fed with SD and HFD for 20–22 weeks. For the glucose analysis 3 experiments were performed in 11–12 WT versus 9–11 KO mice fed with HFD and 6–7 WT versus 5–6 KO mice fed with SD. For the insulin, QUICKI and HOMA-IR analysis, 2 experiments were performed in 11–22 WT versus 9–20 KO mice fed with HFD, and 3–4 WT versus 2–4 KO mice fed with SD. E, G, H Blood glucose (E) and serum insulin concentration (G) during OGTT and blood glucose level during ITT (H) of iRhom2 WT and KO mice fed with SD and HFD for 26–28 weeks. F, I AUC of glucose levels during the OGTT (F) and ITT (I). Three or two independent experiments were performed for OGTT and ITT, respectively. In each, 9–12 HFD-fed mice and 5–7 SD-fed controls were used for all the analysis. Insulin concentration during OGTT was evaluated in 1–4 SD and HFD-fed mice (total of 7 mice per group) from each experiment. J Pancreatic insulin content. Two independent experiments using 3–5 WT versus 3–7 KO mice fed with HFD and 1–5 WT versus 1–3 KO mice fed with SD for 30 weeks. Error bars represent SEM; * represents p < 0.05, ** represents p < 0.01, *** represents p < 0.001, **** represents p < 0.0001.