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. 2019 Dec 6;9:1311. doi: 10.3389/fonc.2019.01311

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Copyright © 2019 Sridharan, Robeson, Bastihalli-Tukaramrao, Howard, Subramaniyan, Tilley, Tiwari and Raman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Targeting eIF4A induces cell death and reduces the self-renewal ability of BCSCs derived from MDA-Bone-Un cells. (A) Immunoblot showing expression levels of eIF4A between the ALDH⁻ and ALDH⁺ and the unsorted, parental MDA-Bone-Un cell populations. (B) RocA-induced cell death in the BCSCs was assessed by DRAQ7 staining and images were captured by light microscopy. DRAQ7 staining is carried out on day 7 following the treatment; Scale bar−400 μm. (C) The viability of cells following RocA treatment was measured by employing CellTiter-Glo assay. (D,E) Represents the reduction in the primary and the secondary MFE following treatment. Data are presented as Mean ± S.E.M. (n = 3). **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001.