Table 3.

Cox Proportional Hazards Regressions of the Incidence of Dementia (2006–2012) on Social Relationship Variables, Excluding Cases in the 24 and 48 Months After Baseline

	Excluding cases in the 24 months after baseline N = 5,352		Excluding cases in the 48 months after baseline N = 4,778
	Adjusted hazards ratio (95% CI)	p	Adjusted hazards ratio (95% CI)	p
Sexa	1.33 (0.96–1.85)	.089	1.58 (1.05–2.36)	.027
Age: 52–59 years	1		1
60–69	1.87 (0.92–3.79)	.083	2.41 (0.96–6.08)	.062
70–79	6.72 (3.52–12.86)	<.001	9.37 (3.96–22.18)	<.001
≥80	20.58 (10.46–40.31)	<.001	33.17 (13.6–80.93)	<.001
Education: Lower	1		1
Intermediate	0.98 (0.70–1.38)	.98	1.12 (0.75–1.68)	.59
Higher	0.99 (0.63–1.57)	.99	0.94 (0.53–1.67)	.83
Wealth (decile)	0.98 (0.92–1.04)	.56	0.99 (0.92–1.06)	.76
Hypertensionb	1.30 (0.96–1.76)	.093	1.55 (1.07–2.25)	.020
Diabetesb	1.42 (0.94–2.15)	.099	1.37 (0.82–2.28)	.23
Strokeb	1.07 (0.65–1.77)	.79	0.94 (0.49–1.79)	.84
Coronary heart diseaseb	1.33 (0.91–1.94)	.14	1.16 (0.71–1.90)	.54
Cancerb	0.95 (0.56–1.61)	.86	1.18 (0.66–2.09)	.58
Mobilityc	1.10 (0.76–1.58)	.63	1.04 (0.67–1.61)	.87
Depresssiond	0.76 (0.35–1.64)	.49	0.59 (0.20–1.71)	.33
Cognition	0.34 (0.27–0.42)	<.001	0.32 (0.24–0.43)	<.001
Marital statuse	1.97 (1.38–2.82)	<.001	2.29 (1.47–3.56)	<.001
Social isolation: 0	1		1
1	1.17 (0.85–1.61)	.32	0.92 (0.12–6.87)	.33
2	1.01 (0.53–1.92)	.97	1.39 (0.67–2.88)	.93
3	1.24 (0.38–4.04)	.78	1.39 (0.95–2.03)	.38
Loneliness	1.45 (1.09–1.93)	.012	1.44 (1.01–2.06)	.045
Close relationships: 0–1	1		1
2–3	0.52 (0.30–0.91)	.021	0.51 (0.25–1.03)	.059
4–5	0.44 (0.25–0.77)	.004	0.44 (0.22–0.89)	.023
6–9	0.41 (0.24–0.68)	.001	0.39 (0.20–0.75)	.005
≥10	0.45 (0.26–0.77)	.003	0.44 (0.23–0.85)	.015

Notes: ^aMale is the reference group.

^bNo illness is the reference group.

^cNo mobility impairment is the reference group.

^dLow depressive symptoms is the reference group.

^eMarried is the reference group.