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. 2019 Nov 13;19(1):33–44. doi: 10.3892/etm.2019.8193

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Copyright: © Eweda et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Light micrographs of the dorsal aorta. The (Aa and Ab) control and (Ca and Cb) sesame lignans-treated group exhibited normal tunica intima with a single irregular layer of endothelial cells (black arrow). The tunica media, comprising elastic fibers and the tunica adventitia also appeared normal. (B_a and B_b) The BPA-treated group exhibited sclerotic changes in the walls and atrophy of elastic fibers (green arrows), loss of the tunica intima endothelial cells, disorganized and vacuolation of the tunica media (blue-arrow), increased adventitial thickness and decreased lumen size of the aorta (double-headed arrows) compared with the control group. (Da and Db) Histological changes induced after BPA-treatment were markedly reduced in the BPA and sesame lignans-treated group (H&E staining; Aa, Ba, Ca and Da magnification, ×200; Ab, Bb, Cb, and Db magnification, ×400). I, tunica intima; M, tunica media; a, tunica adventitia.