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. 2019 Dec 12;50:109. doi: 10.1186/s13567-019-0725-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Differential gene expression. A Volcano plots were used to visualize differential expression between APEC94 and APEC94Δlsr(Cm). Genes with significantly up-regulated expression are indicated with red dots, down-regulated genes are indicated with green dots, and blue dots represent genes with no significant differential expression. The results showed that 62 genes were up-regulated and 415 genes were down-regulated in APECΔlsr(Cm), compared with wild-type strain APEC94 (differentially expressed genes were selected when the fold change was > 2 and the q value < 0.005). B The differentially expressed genes (including up-regulated and down-regulated genes) directly reflected the number and distribution of differentially expressed genes by GO term enriched from three categories: biological progress, cellular component and molecular function. *Represents significantly enriched (p < 0.05).