Table 2.
Mean change in PET Centiloids from OLE baseline to OLE week 52 and OLE week 104 in patients with and without ≥ 1 ARIA-E event
| OLE week 52 | OLE week 104 | |||||||
|---|---|---|---|---|---|---|---|---|
| Patients with ≥ 1 ARIA-E event | MR-DBP (n = 13) | MR-DBA (n = 8) | SR (n = 7) | Total (n = 28) | MR-DBP (n = 6) | MR-DBA (n = 3) | SR (n = 4) | Total (n = 13) |
| Centiloid composite ROI—mean cerebellum gray | ||||||||
| Baseline value, mean (SD) | 90.47 (31.67) | 68.01 (48.78) | 67.19 (38.31) | 78.23 (39.03) | 82.35 (33.94) | 63.94 (41.02) | 78.83 (40.21) | 77.02 (34.97) |
| Value at visit, mean (SD) | 51.38 (23.42) | 11.16 (38.04) | 22.21 (28.82) | 32.60 (33.73) | 18.22 (21.77) | 11.77 (50.63) | 5.18 (24.58) | 12.72 (28.46) |
| Change from baseline, mean (SD) | − 39.09 (30.90) | − 56.85 (29.52) | − 44.98 (33.43) | − 45.64 (30.93) | − 64.13 (20.28) | − 52.17 (28.66) | − 73.65 (33.89) | − 64.30 (25.72) |
| OLE week 52 change from baseline, mean (SD) | NA | NA | NA | NA | − 32.53 (31.50) | − 47.26 (12.93) | − 55.24 (40.53) | − 42.91 (31.01) |
| Patients without an ARIA-E event | MR-DBP (n = 14) | MR-DBA (n = 13) | SR (n = 12) | Total (n = 39) | MR-DBP (n = 10) | MR-DBA (n = 8) | SR (n = 8) | Total (n = 26) |
| Centiloid composite ROI—mean cerebellum gray | ||||||||
| Baseline value, mean (SD) | 91.65 (58.77) | 86.65 (53.87) | 39.39 (58.71) | 73.90 (60.36) | 97.15 (68.72) | 81.59 (66.35) | 65.02 (42.53) | 82.47 (60.19) |
| Value at visit, mean (SD) | 46.93 (45.38) | 44.30 (45.29) | 32.95 (42.31) | 41.75 (43.67) | 25.34 (31.63) | 18.53 (40.38) | 34.64 (34.31) | 26.10 (34.47) |
| Change from baseline, mean (SD) | − 44.72 (38.26) | − 42.35 (21.23) | − 6.45 (53.14) | − 32.15 (41.99) | − 71.81 (48.25) | − 63.06 (32.84) | − 30.38 (17.33) | − 56.37 (39.37) |
| OLE week 52 change from baseline, mean (SD)b | NA | NA | NA | NA | − 41.80 (38.85) | − 46.72 (20.26) | − 18.68 (16.79) | − 36.90 (29.92) |
an = 11 in SR and total n = 38 at OLE week 104
bn = 7 in SR and total n = 25 at OLE week 104