Table 6.
Regional age-adjusted regression estimates of CTE tau pathology
| Neurons with NFT | Neurons with punctate p-tau | Neurite clusters | Dystrophic neurites | |
|---|---|---|---|---|
| PrCa | 0.95 (0.46, 1.44)b *** | 0.89 (0.37, 1.41) *** | 1.59 (0.94, 2.23) *** | 0.88 (0.44, 1.31) *** |
| EC | 0.99 (0.44, 1.54) ** | 0.41 (−0.15, 0.95) | 1.50 (0.75, 2.23) *** | 0.95 (0.93, 0.98) *** |
| DG | 0.77 (−0.10, 1.58) | 1.10 (0.13, 2.05) * | 0.61 (0.50, 0.71) *** | 0.63 (−0.09, 1.34) |
| CA3 | 0.50 (−0.07, 1.06) | 0.19 (−0.62, 0.98) | 0.76 (− 0.20, 1.66) | 0.44 (− 0.12, 0.99) |
| CA1 | 0.67 (0.12, 1.20) * | 0.26 (−0.34, 0.85) | 1.22 (0.55, 1.86) *** | 0.55 (0.05, 1.03) * |
| Sub | 0.69 (0.14, 1.22) * | 0.32 (0.27, 0.38) *** | 1.29 (0.36, 2.17) * | 1.06 (0.34, 1.76) ** |
| PrS | 1.10 (0.55, 1.64) *** | 0.80 (0.16, 1.43) * | 1.12 (0.21, 2.01) * | 0.79 (0.26, 1.30) * |
aPrC Perirhinal cortex, EC Entorhinal cortex, DG Dentate gyrus, CA3 Hippocampus CA3, CA1 Hippocampus CA1, Sub Subiculum, PrS Pre−/parasubiculum
bage-at-death associated regression coefficient (95% confidence interval) with false discovery rate α = 0.03, * p < 0.05, ** p < 0.01, *** p < 0.001