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. 2019 Dec 12;16:263. doi: 10.1186/s12974-019-1646-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — CXCL12/CXCR4 was involved in α-synuclein-induced microglial migration. a The migration of BV-2 cells towards CXCL12 was measured by Transwell assay, and AMD3100 was added to the upper chambers to block the interaction between CXCL12 and CXCR4. b The migration of BV-2 cells induced by α-synuclein was observed with or without pretreatment with a TLR4 inhibitor (TAK242) or an NF-κB inhibitor (PDTC). The data are shown as the mean ± SEM from three independent experiments. *p < 0.05