Table 3.
Diagnostic utility of pathologic markers in mediastinal B-cell lymphomas
| Specificity (CHL, NS) |
Sensitivity (PMLBCL) | NPV (CHL, NS) |
PPV (PMLBCL) |
AUC (95% CI) | p value | DeLong test (p value) | |
|---|---|---|---|---|---|---|---|
| P63 | 84.6% | 93.8% | 91.7% | 88.2% | 0.892 (0.756, 1.000) | < 0.001 | reference |
| GATA3 | 75.0% | 100.0% | 100.0% | 84.2% | 0.875 (0.721, 1.000) | 0.001 | 0.918 |
| IRF4/MUM1 | 100.0% | 50.0% | 61.9% | 100.0% | 0.750 (0.570, 0.930) | 0.023 | 0.133 |
| BCL6 | 100.0% | 56.2% | 63.2% | 100.0% | 0.781 (0.609, 0.954) | 0.012 | 0.276 |
| CD30 | 100.0% | 62.5% | 68.4% | 100.0% | 0.813 (0.651, 0.974) | 0.004 | 0.386 |
| CD23 | 87.5% | 71.4% | 63.6% | 90.9% | 0.795 (0.595, 0.994) | 0.024 | 0.745 |
| EBV | 92.3% | 6.2% | 44.4% | 50.0% | 0.493 (0.278, 0.708) | 0.948 | |
| CyclinE | 100.0% | 12.5% | 46.2% | 100.0% | 0.563 (0.348, 0.777) | 0.577 | |
| Granuloma | 23.1% | 100.0% | 100.0% | 61.5% | 0.615 (0.402, 0.828) | 0.293 | |
| Alveolar fibrosis | 100.0% | 75.0% | 76.5% | 100.0% | 0.875 (0.739, 1.000) | 0.001 | 0.844 |
CHL classic Hodgkin lymphoma; NS, nodular sclerosis; PMLBCL; primary mediastinal diffuse large B-cell lymphoma; NPV negative predictive value; PPV positive predictive value; AUC area under the receiver operating characteristics