Table 4.
Summary of adapted Hudson and Turner Scores in treated animals
| Study Site | Kenya (VSRI) | Zambia (CVRI) | ||||||
|---|---|---|---|---|---|---|---|---|
| Treatment | Saline | Tulathromycin | Gamithromycin | Oxytetracycline | Saline | Tulathromycin | Gamithromycin | Oxytetracycline |
| Number of Cattle | 15 (14*) | 15 | 15 | 15 | 13 | 13 | 13 | 14 |
| Mean serology score (s.d.) | 2.7 (0.8) | 0.8 (1.2) | 1.5 (1.4) | 0.6 (0.8) | 2.15 (1.28) | 0.15 (0.55) | 0.54 (1.05) | 0.43 (1.09) |
| Range | 0–3 | 0–3 | 0–3 | 0–2 | 0–3 | 0–2 | 0–3 | 0–3 |
| Mean clinical scorea (s.d.) | 1.1 (1.5) | 0 (n/a) | 0.2 (0.8) | 0.2 (0.8) | 0.77 (1.30) | 0 | 0 | 0 |
| Range | 0–3 | 0 | 0–3 | 0–3 | 0–3 | 0 | 0 | 0 |
| Mean post-mortem scoreb (s.d.) | 5.2 (4.6) | 0.3 (0.7) | 1.3 (2.7) | 0.4 (1.6) | 5.61 (3.62) | 0 | 0 | 1.29 (2.67) |
| Range | 0–12 | 0–2 | 0–9 | 0–6 | 0–12 | 0 | 0 | 0–8 |
| Mean adapted Hudson & Turner Score (s.d.) | 4.5 (2.5) | 0.8 (1.2) | 2.0 (2.1) | 0.9 (1.0) | 8.54 (4.35) | 0.15 (0.55) | 0.54 (1.05) | 1.71 (3.69) |
| Range | 0–8 | 0–3 | 0–7 | 0–3 | 0–15 | 0–2 | 0–3 | 0–11 |
| p-value for significance (HT Score) | Groups (overall): p ≤ 0.001; s.e. 0.466 | Groups (overall): p ≤ 0.001; s.e. 0.813 (n = 13); 0.783 (n = 14) | ||||||
| Comparison | Group 1 vs. | Group 2 p ≤ 0.001 | Group 3 p ≤ 0.001 | Group 4 p ≤ 0.001 | Group 1 vs | Group 2 p ≤ 0.001 | Group 3 p ≤ 0.001 | Group 4 p ≤ 0.001 |
a Clinical score calculated as a combination of pyrexia and mortality; b Lesion score calculated as a combination of acute/subacute or chronic lung lesion (type and size) and tissue isolation of Mycoplasma. * Tissue samples for one animal were missing, hence n = 14 for PM and overall adapted HT score