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Regions of interest in the coronal plane assessed for Aβ plaque burden. (A) Anterior section (0.2 mm anterior to bregma): 1) septal nucleus and 2) frontal motor/sensory cortex. (B) Posterior section (3.3 mm posterior to bregma): 3) retrosplenial cortex, 4) parietal auditory/sensory cortex, 5) entorhinal cortex, and hippocampus (subdivided into 6) CA1 stratum oriens, 7), CA1 dendritic layers, and 8) dentate gyrus). Figures adapted from Paxinos and Watson.25 Aβ, β-amyloid.
