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. 2019 May 15;30(5):544–555. doi: 10.1089/hum.2018.079

Figure 4.

Figure 4.

Intrathecal injection of rAAV9-CBA-hABCD1 leads to partial biochemical correction in Abcd1–/– mouse spinal cord. (a–c) C26:0 levels in spinal cord, DRG, and liver after intrathecal osmotic pump (IT pump) and intrathecal bolus (IT bolus) delivery of rAAV9-CBA-hABCD1 at 1 × 1011 GC/mouse. (d–f) C24:0 levels in spinal cord, DRG, and liver after intrathecal osmotic pump and bolus delivery at 1 × 1011 GC/mouse. Data are expressed as means ± SEM. ***p < 0.001 compared with wild type; #p < 0.05, ##p < 0.01 compared with PBS control. DRG, dorsal root ganglia; GC, genome copies; PBS, phosphate-buffered saline; WT, wild type.