Table 1.

Summary of Male Adolescent HPV Vaccination Uptake Included in Current Literature Review

Quality	Author(s)	Study design	Study setting	Participants	Previous vaccination uptake	Barriers reported
25	Calo et al.20 Parents' willingness to get HPV vaccination for their adolescent children at a pharmacy	Quantitative National web-based survey	Recruited from a random national panel of US adults using random digit dialing, address based, or email with age-eligible male adolescents (11–17-year old)	672 parents of 11–17-year-old male adolescents Parents were members of a standing, national panel of US adults maintained by survey research company 52% female 71% White, 13% Hispanic, 9% non-Hispanic Black 38% high school degree or less, 62% some college or more	64% no vaccine at beginning of study 24% no vaccine at conclusion 36% received one or two doses	Only 29% would get sons vaccinated at pharmacies 55% did not receive physician recommendation 34% thought the HPV vaccine as more important, 25% thought of it as less important 18% believes that sons as young as 11 could get HPV vaccine 70% were unaware that males as young as 11 could receive the vaccine 37% said they would like to find out about pharmacy vaccinations through physician
24	Farias et al.30 Association of physicians perceived barriers with HPV vaccination initiation	Quantitative (web-based survey and electronic medical records) Pediatricians' perceived barriers to vaccinating adolescents 11–18 years of age	Recruited providers from the Texas Children's Pediatrics—a large network of clinics in Houston, TX Compared to medical records (electronic) of HPV vaccination initiation over 12 months	134 providers (36.6% under 40, 29.6% 40–49, 17.2% 50–59, and 16.4% over 60) Most were White (50%), Black (9%), or Hispanic (9.7%) 70.2% female, 29.9% male	18.6% reported initiating the vaccine regimen among 36,827 patients	18.7% reported barriers concerning level of knowledge about HPV 25.4% had concerns about parents' negative reaction about the HPV vaccine 73.1% reported discomfort talking about STIs with parents/patients 25.4% reported concern of financial burden on patients 15.7% concerned about vaccine safety 10.5% concerned about vaccine efficacy 70.9% not required for school attendance 64.2% concerned with the time it takes to discuss HPV vaccine 73.1% difficulty ensuring three-dose regimen among patients 82.8% infrequent office visits by patients
24	Greenfield et al.33 Strategies for increasing adolescent immunizations in diverse and ethnic communities	Mixed methods (in-person surveys and three focus groups) Conducted with mothers of 11–18-year-old males who were Hispanic, Ethiopian, and/or Somali from King County, Washington	Three school systems of Burien, SeaTac, and Tukwila (the top three most diverse cities in Washington)	157 parents (mean age 41) and 45 adolescent males (mean age 15) Parents were 35% Somali, 33% Hispanic, and 32% Ethiopian; 99% foreign born Adolescents were 38% Somali, 27% Hispanic, and 36% Ethiopian; 60% foreign born	Reported by parent: 0% of Somali sons 40% of Hispanic sons 16% of Ethiopian sons Reported by sons: 0% of Somali sons 30% of Hispanic sons 20% of Ethiopian sons	Surveys: 38% of parents heard of HPV in males Parents reported their main reason for not vaccinating was not knowing that vaccines were recommended 22% of sons heard of HPV 25% of sons had heard of the HPV vaccine Focus groups: Parents did not trust recommendations from pharmacists or school nurses—lack of trust Nearly universal to vaccinate if recommended to do so by physician Existing misconceptions regarding the HPV vaccine, severity of HPV, complications, and how it is transmitted Parents expressed a desire to access vaccine information in their native language
24	Griebeler et al.28 Parental beliefs and knowledge about male HPV vaccination in the US: A survey of a pediatric clinic population	Quantitative (in-person surveys)	Convenience sample of a low-income, Medicaid pediatric clinic in the US	102 parents of male adolescents 9–20 years of age Pediatric clinic demographics: 75% utilized Medicaid 85% White and 10% Black No participant demographics were collected for anonymity purposes	66% of parents with sons younger than 12 have been vaccinated	Majority of parents reported some knowledge of HPV (50%) or nothing (38%), followed by a lot (11%) 13% thought male HPV is not serious 8% thought that vaccines are against personal beliefs 38% were concerned of vaccine safety (new vaccine) Child does not want to be vaccinated (4%) Child is too young (38%) Only 14% answered all knowledge questions correctly 30% were unable to identify any health outcomes of HPV in males Of those that didn't vaccinate: 54% fulfilled child's wish to not be vaccinated; 38% reported child was too young/feared that vaccine would negatively affect child behavior
24	Reiter et al.17 Default policies and parents' consent for school-located HPV vaccination	Quantitative (experimental, 3 × 2 between-subjects factorial design)	Recruited parents through an existing online, national survey of US HIS households Only looked at parental response in this article	Parents: 404 parents of males 11–17 years of age 61% younger than 45 years, 67% were non-Hispanic White, 14% Black, 15% Hispanic, and 82% lived in an urban area Sons: 404 sons—28% 11–12 years, 37% 13–15 years, and 35% 16–17 years 63% White, 12% Black, and 15% Hispanic	0% of sons	Parents: 29.9% more likely to opt in if vaccinated at school 62% of the control group did not differ from opt in or out 70% did not know whether they will vaccinate their sons in the next year More likely to vaccinate if vaccinated with other vaccines rather than by itself
23	Tan and Gerbie27 Perception, awareness, and acceptance of HPV disease and vaccine among parents of boys 9–18 years of age	Quantitative (in-person paper survey—given in both English and Spanish)	Recruited parents of boys 9–18 years of age, who obtained primary care from pediatrician or public health clinics in Chicago, IL, from 2011 to 2013	516 parents (mean age of 41.5) of males 9–18 years of age PCP Parents: 77.39% White, 9.57% Black, 4.4% Hispanic, and 4.7% Asian 97.3% private health insurance Public health parents: 5.59% White, 25.52% Black, 62.24% Hispanic, and 4.55% Asian 92.31% Medicaid	0% of sons 44.35% of the PCP parental group would vaccinate, but 94.55% said that they would only if a physician recommended it	PCP parental group: 91.74% had heard of HPV and 86.96% heard of the vaccine 44.35% knew about the HPV vaccine for males 39.13% responded “Don't know” when asked what diseases HPV caused, but 36.52% knew that it caused genital warts 53.91% knew it was a common infection, and was sexually transmitted (76.52%) Few knew that it caused cancer in males (16.96%) Public health parental group: 65.93% have heard of HPV and 55.24% heard of the vaccine 26.92% knew about the HPV vaccine for males 68.53% did not know what HPV caused, but 16.43% knew it caused genital warts 33.33% knew it was a common infection, and 50.35% knew it was sexually transmitted 18.82% knew it caused cancer in males
23	Schuler and Coyne-Beasley43 Has their son been vaccinated? Beliefs about other parents matter for HPV vaccine	Quantitative (cross-sectional, in-person, self-administered survey)	Pediatric clinic that provides pediatric and subspecialty care in North Carolina	267 parents of sons 9–21 years of age 48% younger than 40 21% male, 79% female 51% White, 40% Black, and 9% other 94% non-Hispanic 55% married 19% had sons 9–10 years, 18% 11–12 years, and 63% 13–21 years	0% of sons 63% of parents were probably going to vaccinate within the next year 8% would definitely not vaccinate	15–18% of parents had correct answers regarding anal, penile, and oropharyngeal cancers caused by HPV 29% of parents would not vaccinate their sons in the next year Parents who had others in their community vaccinating their sons the same age were 4 × more likely to vaccinate sons in the next year 59% of parents were worried HPV vaccines cause unknown, long-term side effects
23	Schuler, DeSousa, and Coyne-Beasley40 Parents' decisions about HPV vaccine for sons: The importance of protecting sons' future female partners	Quantitative (cross-sectional, in-person, self-administered survey) about sons	Pediatric clinic that provides pediatric and subspecialty care serving those 21 years and younger in North Carolina	246 parents of sons 9–21 years of age 51% younger than 40 21% male, 79% female 52% White, 40% Black, and 8% other 57% married 21% 9–10 years, 20% 11–12 years, and 59% 13–21 years	0% of sons	76% would vaccinate sons to protect future female partners, and those who were not concerned about this were less likely to vaccinate 15% said they would vaccinate in the next year, 30% said that they would probably not vaccinate, and 8% said they would definitely not vaccinate Parents 40 years of age and older (83%) indicated that female partner protection would likely influence vaccine decisions compared to younger parents (70%)
23	Cates et al.21 Designing messages to motivate parents to get their preteenage sons vaccinated against HPV	Mixed methods Five focus groups and interviews from 2009 to 2010	Focus groups: Recruited from churches and a middle school in rural Sampson county, North Carolina, through flyers and announcements Interviews: Completed at pediatric and adolescent health clinic affiliated with UNC Chapel Hill, recruited parents from university-based health clinics	Focus groups: 29 parents of 11–12-year-old boys; 76% female, 67% older than 40, 100% Black Interviews: 100 parents of 9–13-year-old boys; 77% female, 46% Black, 44% White, and 10% other; 69% mothers, 19% fathers, and 12% other relatives	Interview: 6% of sons had received first dose 16% said they would “definitely” or “probably” get sons vaccinated within 12 months	Focus groups: Low awareness of HPV (unaware of serious consequences for males or that males could get HPV) Low awareness of the HPV vaccine Perceived susceptibility/severity of HPV in males (thought son at risk if they were sexually active) Three-dose series cost too much Vaccine side effects Long-term safety and effectiveness Feeling like “guinea pigs,” compared the HPV vaccine to the syphilis study in the past Interviews: 11% heard about the HPV vaccine for males 48% reported concerns for vaccine safety and side effects 25% were unaware of the male prevalence of HPV 19% were distracted by number of doses needed
23	Oldach and Katz42 Ohio Appalachia public health department personnel: HPV vaccine availability, and acceptance and concerns among parents of male and female adolescents	Qualitative (semistructured telephone/questionnaire interviews)	Health departments in Appalachian Ohio identified through the Ohio Department of Health (ODH) website Member of research teams called each health department to schedule telephone interview	46 public health departments and lead providers in those departments (32 county level, 14 city level) 24 public health nurses, 21 directors of public health nursing, and 1 public health supervisor Race/ethnicity was not reported	N/A	Provider barriers: 55.6% lack of knowledge about HPV in males 37.8% concern about vaccine side effects 35.6% new vaccine concerns 35.6% patients are not sexually active or too young 22.2% negative publicity form media or community 15.6% vaccine causes sexual promiscuity 15.6% vaccine not mandatory 13.3% difficulty discussing HPV vaccine 8.9% vaccine series completion rate 6.7% patient does n0t like vaccines (e.g., pain) 4.4% no vaccination because of religious beliefs Provider-reported parental barriers: 44.4% unaware of vaccine for males 13.3% knew more information about the HPV vaccine and females 35.6% had lack of knowledge of why males should receive the HPV vaccine 11.1% of parents perceived HPV as less severe as other STIs
22	Thompson et al.35 HPV vaccination: What are the reasons for nonvaccination among US adolescents?	Mixed methods (parent telephone interview, and then provider survey to verify vaccination status)	Recruited from NIS-teen survey from 2010 to 2012 and contacted a second time for interview	59,897 parents of male adolescents from 2010 to 2014 58.8% of parents had adolescent sons 68% were female, 25.6% male, 3.0% grandparents Race/ethnicity was not reported	0% overall vaccination uptake 51.9% reported not getting their son vaccinated 31.6% were unlikely to receive the vaccine	Most parents who did not vaccinate sons (or said that they would not) did so because they believed that the HPV vaccine is not needed for males Among those who chose not to be vaccinated, lack of knowledge was a major factor Sons are not sexually active Vaccine was not recommended Safety and side effects caused by the HPV vaccine were a concern
22	Luque et al.32 Recommendations and administration of the HPV vaccine to 11- to 12-year-old girls and boys: A statewide survey of Georgia vaccines for children provider practices	Quantitative cross-sectional (web-based, paper, and telephone self-administered survey)	Recruited providers from 206 locations in GA through the GA vaccines for children provider list from 2010 to 2011 Probability 1-stage cluster sampling with counties as clusters	217 providers (mean age of 51 years) 59% were White, 20% Black, 14% Asian And 94% non-Hispanic 57% male Mean number of years since residency training was 18 years	N/A	12% vaccine safety and efficacy 17% new vaccine with limited track record 15% adding another vaccine to schedule 12% lack of information about the vaccine 69% upfront cost of purchasing vaccine was high 73% cost of stocking vaccine 68% lack of reimbursement for vaccine from insurance 63% failure of insurance coverage in males 15% lack of time to discuss vaccine with patients 51% difficulty ensuring the three-dose regimen 23% vaccine not required for school 20% of providers would always recommend male patients get vaccinated
21	Reiter et al.23 Early adoption of the HPV vaccine among Hispanic adolescent males in the US	Quantitative (secondary analysis of national, telephone survey)	Recruited parents through an existing online, NIS-teen from 2010 to 2012	Parents: 4238 parents of adolescent sons (13–17 years old) Majority of mothers were at least 35 years (86%) and did not have college degrees (81.6%) Sons: 100% of sons were Hispanic; 86.1% of sons were Hispanic-White, 5.6% Black, and 8.3% other mixed Most sons were 13–15 years of age (62.4%)	Initiation: 17.1% received at least one dose Initiation increased each year to 2.8% in 2010, 14.9% in 2011, and 31.7% in 2012 Overall: 5.5% of adolescent Hispanic males completed all three doses	Parents: 23.6% reported lack of knowledge about HPV 40.2% was not sure about vaccination over the next year or not likely at all 22.5% believed vaccine is not needed 22% did not have provider recommendation Spanish-speaking parents were more likely to indicate lack of knowledge (19.9% vs. 32.9%) and not receiving a provider recommendation (17.7% vs. 32.2%) than English-speaking patients English-speaking parents were more likely to indicate believing vaccinations as not needed (27.2% vs. 10.6%), that their son was not sexually active (11.2% vs. 3.5%), that their child is male, therefore did not need the vaccine (7.5% vs. 2.2%), and being concerned about vaccine safety and side effects (6.8% vs. 3.1%)
21	Reiter et al.17,36 Improving HPV vaccine delivery: A national study of parents and their adolescent sons	Quantitative (cross-sectional, web-based, self-administered survey) Dual-approach (list-assisted random-digit dialing and address-based sampling)	Recruited parents through an existing online, national survey of US households	Parents: 506 parents—54% female, most 45 years of age or younger (61%) Majority non-Hispanic White (67%), Black (12%), and Hispanic (15%); with some college or more (56%) Sons: 391 sons—30% 11–12 years, 38% 13–15 years, or 31% 16–17 years Majority non-Hispanic White (61%), Black (12%), or Hispanic (16%) 79% saw physician within past year	0%	Parents Preferred for child be vaccinated at doctor's office Preferred brief nurse visits for vaccination (65%) rather than pharmacy vaccination 29% believed insurance would not cover vaccination at school Sons Preferred to be vaccinated at doctor's office for initial vaccine; and a brief nurse visits for vaccination for two last shots 32% were embarrassed to be vaccinated
21	Reiter et al.16 HPV vaccine and adolescent males	Quantitative (web-based, self-administered survey)	Recruited parents of adolescent sons 11–17 years of age (and later sons) from an existing national panel of US households	Parents: 547 participants (61% younger than 45) 67% White, 13% Black, 15% Hispanic, and 5% other; majority were married (82%) Sons: 421 participants (30% 11–12 years, 38% 13–15 years, and 32% 16–17 years) 61% White, 12% Black, and 16% Hispanic	2% of sons received any HPV vaccine dosage <1% received all three doses	Parents: 0.48% talked to sons about vaccine 21% sons' insurance covers vaccine 0.75% worry about sons getting HPV 0.93% perceive effectiveness of vaccine 0.67% perceived uncertainty about vaccine 0.53% perceived harms of HPV vaccine 80% were unaware that the HPV vaccine can be given to males 43% would give vaccine to son if it was free Sons: 75% had never heard of HPV 0.67% perceived themselves getting HPV 0.41% amount talking with parents about vaccine 0.60% reported peer acceptance of vaccine 1.06% anticipated embarrassment of getting HPV vaccine Sons willingness to get vaccinated was positively correlated to parent's willingness to get them a free HPV vaccine Reported high anticipated regret if they did not vaccinate and later got HPV or genital warts
20	Alexander et al.24 What parents and their adolescent sons suggest for male HPV vaccine messaging	Qualitative (30–60 minutes in-person, semistructured interviews) Parent–son dyads interviewed about how they felt about vaccination uptake and series completion, demographic questionnaire	Recruited from primary care clinics in Indianapolis, IN, from low- to middle-income families 23 dyads were approached for participation, only 21 participated Parents and sons were interviewed simultaneously, but in separate rooms and interviewers	21 adolescent males (13–17 years of age) parent–son dyads (42 separate interviews) Sons: Black (n = 14), Hispanic (n = 5), and White (n = 2) ranging from 13 to 17 years of age Parents: Majority were female (n = 17), ranging in age 31–53, majority were single (n = 12), half had at least a high school education (n = 11)	0%	Sons: Felt it was important for a provider recommendation Side effect of vaccines Sons also noted misinformation (e.g., should get vaccine before sexual initiation, available to males, prevention of STIs, genital warts, and cancer) Parents: Side effects of vaccines and fear for sons' health Doses were spaced too far apart Do not want children to feel like “guinea pigs” Did not receive provider recommendation Cost of HPV vaccine too high Length of three-dose regimen Time since the approval of HPV vaccine
20	Reiter et al.22 Longitudinal predictors of HPV vaccination among a national sample of adolescent males	Quantitative Longitudinal (two time points) Web-based, self-administered surveys Part of the HIS study	Recruited parents through an existing online, national survey of US households (dual-frame sampling approach) Panel maintained by a survey company	Baseline: 547 parents, 421 sons (11–17 years) Follow-up: 327 parents, 228 sons Parents: 59% younger than 45 years 68% White, 80% married, 60% college education, 84% lived in urban areas, 32% born-again Christian, 52% female Sons: 65% White, 30% 11–12 years, 37% 13–15 years, and 33% 16–17 years	Baseline: 2% of parents had sons who had initiated the HPV vaccine regimen Follow-up: 6% had sons who received at least one dose of the HPV vaccine 8% had initiated the regimen 4% had received all doses	Baseline vs. follow-up: 11% did not know enough about the HPV vaccine vs. 23% at follow-up 10% did not receive a doctor recommendation vs. 17% at follow-up 6% thought vaccine is unsafe vs. 10% at follow-up 4% were worried because vaccine is new vs. 8% at follow-up 3% did not have recent doctor appointment vs. 11% at follow-up 23% did not know boys can get HPV vs. 5% at follow-up 6% believed their sons were too young vs. 2% at follow-up 55% who received a recommendation vaccinated son vs. 1% at follow-up
19	Finney Rutten et al.31 Clinician knowledge, clinician barriers, and perceived parental barriers regarding HPV vaccination: Association with initiation and completion rates	Quantitative (web-based survey and secondary data extraction) Data reported on 9–18-year-old patients residing in the same 27-county geographic region from 2015 to 2016	Recruited from Rochester Epidemiology Project across 27 counties in Olmsted county, MN	280 providers and nurses from 52 clinic sites (70% providers, 26.8% nurses) 86.1% non-Hispanic White, 13.9% other	11.407 (11.7%) patients had initiated series 5.267 (43.0%) completed vaccination series within study timeframe	Clinician-reported barriers: 38.9% incorrectly agreed that genital warts were caused by the same HPV types as cervical cancer 43.2% concerned about vaccine safety 41.8% had difficulty discussing sexuality and STIs 43.6% difficulty adding new vaccine to vaccine schedule Vaccine not required for school admittance (50.4%) Perceived parental barriers: 54% limited HPV knowledge 49.8% parental request of vaccine deferment 48.6% thought child was not at risk for HPV 36.1% parental reluctance to discuss sexuality and STIs 34.7% thought child was too young
19	Bhatta and Phillips34 HPV vaccine awareness, uptake, and parental and health care provider communication among 11- to 18-year-old adolescents in rural Appalachian Ohio county in the US	Quantitative longitudinal Secondary data analysis of the self-administered survey, 2012 Youth Risk Behavior Surveillance System from additional five questions	Middle school and high school classrooms within a rural county located in Northeast Ohio Appalachia	674 sons (11–18 years of age) out of 1299 participants (separate male/female statistical analyses) 90.3% were non-Hispanic White 3% were 11 years of age	0% beginning 62.3% were never vaccinated 3.8% received one dose 1.9% received two doses 0.9% received all three doses	Sons (24.0%) had less HPV awareness than female counterparts (36.6%) Younger age Lack of communication with parents 42.1% sons knew what the HPV vaccine was 13% parents talked about the HPV vaccine 14.4% physicians talked about the HPV vaccine 11.5% sons reported ever receiving the HPV vaccine
19	Khurana et al.15 HPV vaccine acceptance among adolescent males and their parents in two suburban pediatric practices	Cross-sectional quantitative Self-administered surveys completed with parent (<18 years, or by self if 18 years or older)	Pediatric clinics in suburbs in Maryland between 2011 and 2012 Parents were recruited by pediatricians during medical visits at two private solo visits in pediatric practices in Maryland	Sons: 154 sons 11–21 years of age (mean age 14.9 years); 71.7% White, 15.1% Asian, 13.2% other Parents: 121 parents (mean age 45.8 years); 72.3% White, 17.6% Asian, and 10.1% other Most were college educated and middle class	0%	Sons: 15.5% accepted vaccine, 27% did not, 57.4% did not know 38.3% heard of HPV 33.1% heard of the HPV vaccine, 8.5% had family/friends received vaccine 60.5% would accept if it protects against warts Adolescents who were sexually active were 4 × more likely to accept vaccine 61.4% would accept if it protects partners from cervical cancer Parents: 31.9% accepted vaccine, 18.5% did not, 49.6% did not know 90% heard of HPV 81.5% heard of the HPV vaccine 32.8% had family/friends receive vaccine 70.6% would accept if it protects against warts 63.6% would accept if it protects partners from cervical cancer
19	Alexander et al.29 Parent–son decision-making about HPV vaccination: A qualitative analysis	Qualitative (30–60 minutes in-person, semistructured interviews) Parent–son dyads asked about decision to vaccinate and physician vaccination recommendation	Recruited from primary care clinics in Indianapolis, IN, from low- to middle-income families Parents and sons were interviewed simultaneously, but in separate rooms and interviewers	21 adolescent males (13–17 years of age) parent–son dyads (42 separate interviews) Sons: Black (n = 14), Hispanic (n = 5), and White (n = 2) ranging from 13 to 17 years Parents: Majority were female (n = 17), ranging in age 31–53, majority were single (n = 12), half had at least a high school education (n = 11)	0%	Parents: Vaccine was optional Questions about sex from son Limited ability to monitor sons' activities Potential risks with the vaccine (n = 2) Physician talked about genital warts Vaccine safety Prevention against cancer and genital warts Availability for males A subset talking about cervical cancer in girls Sons: Pain is most common concern (e.g., get shot in penis) Many felt as though this was the first health care decision that they had been involved in
18	Agawu et al.37 Sociodemographic differences in HPV vaccine initiation by adolescent males	Quantitative (retrospective cohort study; medical record extraction)	Network of primary care practices affiliated with a large metropolitan children's hospital located in Pennsylvania and New Jersey Recruited from preventative or acute appointments	58,757 sons 11–18 years of age 57.3% non-Hispanic White, 27.6% non-Hispanic Black 76.9% private insurance	0% beginning Blacks vaccinated most (53.7%), then Hispanics (44.1%), then Whites (33.1%) 20,465 (77.6%) vaccinated within 2 years of first visit 39% initiated overall 6.9% vaccinated at first visit	No/poor insurance (being on Medicaid or no insurance) Racial subgroups with Medicaid were more likely to initiate vaccine series than those with private insurance Non-Hispanic White participants were less likely to initiate HPV vaccine series Black participants most likely to vaccinate then Hispanics
17	Liddon et al.39 Provider attitudes toward HPV vaccine for males	Quantitative, systematic review (secondary data analysis discussing research design and outcomes reported)	HPV vaccine acceptance in males quantitative or qualitative data	23 published articles (half published in the US) 87% quantitative, 13% qualitative Most used convenience samples (74%) and 26% relied on nationally representative samples	NA	Providers are likely to recommend the HPV vaccine to male adolescents, but are more likely to recommend it to those 13–18 years of age Most offer the vaccine to males to protect future female partners 59% believe the vaccine would provide an opportunity to discuss sexual health with adolescent patients Younger children are less likely to have preventative health care visits or see physicians for vaccination series 81% adolescent males had either not heard of HPV or had low HPV knowledge

HIS, HPV Immunization in Sons; HPV, human papillomavirus; N/A, not applicable; NIS, national teen immunization survey; PCP, primary care physician; STI, sexually transmitted infection; US, United States.