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. 2019 May 21;30(5):590–600. doi: 10.1089/hum.2018.156

Figure 4.

Figure 4.

Sections of mouse eyes stained for ABCA4 (green) and Hcn1 (red). Nuclei were stained with Hoescht. (A) Abca4 staining in photoreceptor outer segments of WT SVEV 129. (B) Absence of Abca4 staining in uninjected Abca4−/− (C) Absence of ABCA4 in upstream vector injected Abca4−/−. (D) Absence of ABCA4 staining in downstream vector injected Abca4−/−. (E) ABCA4 staining in photoreceptor outer segments of dual vector injected Abca4−/−. Dual, dual vector injected; Downstream, downstream vector injected; Hcn1, hyperpolarization activated cyclic nucleotide gated potassium channel 1 (inner segment marker); IS, inner segments; ONL, outer nuclear layer; OS, outer segments; RPE, retinal pigment epithelium; Upstream, upstream vector injected Abca4−/−; WT, SVEV wild type.